Tato bakalářská práce je zaměřena na vícejaderné magnetické částice, jejich fyzikální a chemické vlastnosti, syntézu a aplikace, zvláště na léčbu nádorových onemocnění pomocí magnetické hypertermie. Nedávno bylo ukázáno, že vícejaderné magnetické částice mohou být efektivnější než jednotlivé nanočástice z hlediska generování tepla pod vlivem externího střídavého magnetického pole, a takto zvýšit léčebný efekt hypertermie. Nicméně, mechanismus generování tepla v takových materiálech není ještě zcela jasný. Experimentální část této práce se právě proto zaměřuje na stanovení souvislosti mezi magneto-strukturálními vlastnostmi vícejaderných magnetických částic a jejich chováním pod vlivem externího střídavého magnetického pole.
Annotation in English
This bachelor's thesis is devoted to multicore magnetic particles, their physical and chemical properties, synthesis and applications with a special focus on magnetic hyperthermia tumor treatment. Recently it was demonstrated that multicore magnetic particles could be superior over single nanoparticles in heat generation under exposure to an external alternating magnetic field, and thus could enhance the therapeutic effect of hyperthermia. However, the mechanism of heat generation in such materials is not clear yet. The experimental part of the current thesis focuses on the establishment of the correlation between magneto-structural properties of the multicore magnetic particles and their performance under exposure to an external alternating magnetic field.
iron oxide, multicore particles, magnetic interaction, magnetic colloid, specific loss power, nanomagnetism, hyperthermia
Length of the covering note
59
Language
AN
Annotation
Tato bakalářská práce je zaměřena na vícejaderné magnetické částice, jejich fyzikální a chemické vlastnosti, syntézu a aplikace, zvláště na léčbu nádorových onemocnění pomocí magnetické hypertermie. Nedávno bylo ukázáno, že vícejaderné magnetické částice mohou být efektivnější než jednotlivé nanočástice z hlediska generování tepla pod vlivem externího střídavého magnetického pole, a takto zvýšit léčebný efekt hypertermie. Nicméně, mechanismus generování tepla v takových materiálech není ještě zcela jasný. Experimentální část této práce se právě proto zaměřuje na stanovení souvislosti mezi magneto-strukturálními vlastnostmi vícejaderných magnetických částic a jejich chováním pod vlivem externího střídavého magnetického pole.
Annotation in English
This bachelor's thesis is devoted to multicore magnetic particles, their physical and chemical properties, synthesis and applications with a special focus on magnetic hyperthermia tumor treatment. Recently it was demonstrated that multicore magnetic particles could be superior over single nanoparticles in heat generation under exposure to an external alternating magnetic field, and thus could enhance the therapeutic effect of hyperthermia. However, the mechanism of heat generation in such materials is not clear yet. The experimental part of the current thesis focuses on the establishment of the correlation between magneto-structural properties of the multicore magnetic particles and their performance under exposure to an external alternating magnetic field.
iron oxide, multicore particles, magnetic interaction, magnetic colloid, specific loss power, nanomagnetism, hyperthermia
Research Plan
The student should perform the literature review on the magnetic iron oxide nanoparticles properties and application for magnetic hyperthermia cancer treatment. Multicore magnetic particles, their properties, ways of synthesis and advantages over single-core nanoparticles should be considered in more details. The literature sources used should be cited in a proper way.
The student should get the experience in chemical laboratory work, methods of magnetic particles synthesis and characterization of their magneto-structural properties.
The student should perform the synthesis of samples of multicore magnetic particles with different morphology and magnetic interaction between them and correlate the synthesis parameters, properties of the dispersion medium with the magneto-structural properties of particles and their heating efficiency in alternating magnetic field.
The student should present the obtained results in a proper way and perform their discussion.
Research Plan
The student should perform the literature review on the magnetic iron oxide nanoparticles properties and application for magnetic hyperthermia cancer treatment. Multicore magnetic particles, their properties, ways of synthesis and advantages over single-core nanoparticles should be considered in more details. The literature sources used should be cited in a proper way.
The student should get the experience in chemical laboratory work, methods of magnetic particles synthesis and characterization of their magneto-structural properties.
The student should perform the synthesis of samples of multicore magnetic particles with different morphology and magnetic interaction between them and correlate the synthesis parameters, properties of the dispersion medium with the magneto-structural properties of particles and their heating efficiency in alternating magnetic field.
The student should present the obtained results in a proper way and perform their discussion.
Recommended resources
R.M. Cornell, U. Schwertmann, The iron oxides: structure, properties, reactions, occurrences, and uses, 2nd, completely rev. and extended ed., Wiley-VCH, Weinheim, 2003.
G. Cao, Nanostructures & nanomaterials: synthesis, properties & applications, Imperial College Press, London, 2004.
Q.A. Pankhurst, J. Connolly, S.K. Jones, J. Dobson, Applications of magnetic nanoparticles in biomedicine, J Phys D Appl Phys, 36 (2003) R167-R181.
S. Dutz, R. Hergt, Magnetic particle hyperthermia-a promising tumour therapy?, Nanotechnology, 25 (2014).
P. de la Presa, Y. Luengo, V. Velasco, M.P. Morales, M. Iglesias, S. Veintemillas-Verdaguer, P. Crespo, A. Hernando, Particle Interactions in Liquid Magnetic Colloids by Zero Field Cooled Measurements: Effects on Heating Efficiency, J Phys Chem C, 119 (2015) 11022-11030.
Recommended resources
R.M. Cornell, U. Schwertmann, The iron oxides: structure, properties, reactions, occurrences, and uses, 2nd, completely rev. and extended ed., Wiley-VCH, Weinheim, 2003.
G. Cao, Nanostructures & nanomaterials: synthesis, properties & applications, Imperial College Press, London, 2004.
Q.A. Pankhurst, J. Connolly, S.K. Jones, J. Dobson, Applications of magnetic nanoparticles in biomedicine, J Phys D Appl Phys, 36 (2003) R167-R181.
S. Dutz, R. Hergt, Magnetic particle hyperthermia-a promising tumour therapy?, Nanotechnology, 25 (2014).
P. de la Presa, Y. Luengo, V. Velasco, M.P. Morales, M. Iglesias, S. Veintemillas-Verdaguer, P. Crespo, A. Hernando, Particle Interactions in Liquid Magnetic Colloids by Zero Field Cooled Measurements: Effects on Heating Efficiency, J Phys Chem C, 119 (2015) 11022-11030.
