Hyaluronan vo vodnom prostredí degraduje a jeho molárna hmotnosť klesá. Degradácia je ovplyvnená teplotou, zložením roztoku a tiež jeho pH. Cieľom diplomovej práce bude štúdium vplyvu rôznych iontov na chovanie hyaluronanu vo vodnom prostredí. S použitím v medicíne, bude štúdium zamerané na fyziologické kompatibilné kationty a anionty.
Annotation in English
The hyaluronan leads to degradation in water solution, its molecular weight decrease. The degradation of hyaluronan is influenced by temperature, solution composition and also its pH. Aim of diploma thesis will be study of different ions influence to hyaluronan behaviour in water solution. In connection with medical application of hyaluronan, the study will be namely focused on physiological compatible cations and anions.
hyaluronan, kinematic viscosity, ion solution, polyelectrolyte
Length of the covering note
60 s.,
Language
CZ
Annotation
Hyaluronan vo vodnom prostredí degraduje a jeho molárna hmotnosť klesá. Degradácia je ovplyvnená teplotou, zložením roztoku a tiež jeho pH. Cieľom diplomovej práce bude štúdium vplyvu rôznych iontov na chovanie hyaluronanu vo vodnom prostredí. S použitím v medicíne, bude štúdium zamerané na fyziologické kompatibilné kationty a anionty.
Annotation in English
The hyaluronan leads to degradation in water solution, its molecular weight decrease. The degradation of hyaluronan is influenced by temperature, solution composition and also its pH. Aim of diploma thesis will be study of different ions influence to hyaluronan behaviour in water solution. In connection with medical application of hyaluronan, the study will be namely focused on physiological compatible cations and anions.
hyaluronan, kinematic viscosity, ion solution, polyelectrolyte
Research Plan
To elaborate of literature search following thesis theme.
To make experiments on prepared samples in CPN Ltd. laboratories (Hyaluronan solution with different ions, the main experimental techniques: Ubbelohde viscosimeter, size of particles measurements).
To discussed results with diploma supervisor.
Research Plan
To elaborate of literature search following thesis theme.
To make experiments on prepared samples in CPN Ltd. laboratories (Hyaluronan solution with different ions, the main experimental techniques: Ubbelohde viscosimeter, size of particles measurements).
To discussed results with diploma supervisor.
Recommended resources
O.Wein: "Úvod do reologie.", Učební texty vysokých škol, Fakulta chemická VUT Brno, Brno (1996.
Carreau P.J., De Kee D.C.R., Chhabra R.P.: Rheology of Polymeric Systems, Hanser Publishers, Munchen (1997).
Goodwin J., Hughes R.W.: Rheology for Chemists, Royal Society of Chemistry, London (2000).
Related papers from international journals.
Recommended resources
O.Wein: "Úvod do reologie.", Učební texty vysokých škol, Fakulta chemická VUT Brno, Brno (1996.
Carreau P.J., De Kee D.C.R., Chhabra R.P.: Rheology of Polymeric Systems, Hanser Publishers, Munchen (1997).
Goodwin J., Hughes R.W.: Rheology for Chemists, Royal Society of Chemistry, London (2000).
