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Lecturer(s)
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Minařík Antonín, doc. Ing. Ph.D.
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Kadlečková Markéta, Ing. Ph.D.
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Kocourková Karolína, Ing. Ph.D.
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Víchová Zdenka, doc. Ing. Ph.D.
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Humpolíček Petr, prof. Ing. Ph.D.
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Vícha Jan, Mgr. Ph.D.
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Course content
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- Definition of biomaterials; natural and synthetic biomaterials. - Principles of biomimetics; biocompatibility; bioinspired materials, tissue engineering, regenerative medicine. - Types, chemical structure and physical properties of biomaterials. Description of the basic building units and the influence of their arrangement on the resulting properties of biomaterials. - Interaction of biomaterials with cells, tissues and the immune system. - Interaction of biomaterials with extracellular matter. - Interaction of biomaterials with blood and proteins. - Surface properties of biomaterials. - Modification of surface properties. - Mechanical and electrical properties of biomaterials. - Biodegradation of biomaterials. - Fundamentals of medical device technology. - Key issues in biomaterials development. - Bioreactors and Lab on the chip technologies. - In vivo and clinical case studies.
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Learning activities and teaching methods
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Lecturing, Practice exercises, Individual work of students
- Preparation for examination
- 120 hours per semester
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| learning outcomes |
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| Knowledge |
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| Knows the types of materials used for the preparation of biomaterials and the differences between them. |
| Knows the types of materials used for the preparation of biomaterials and the differences between them. |
| Distinguishes between the chemical and physical properties of biomaterials. |
| Distinguishes between the chemical and physical properties of biomaterials. |
| Understands the effect of building junctions and their arrangement on the resulting properties. |
| Understands the effect of building junctions and their arrangement on the resulting properties. |
| Knows the basic principles of interaction between biomaterials and living systems. |
| Knows the basic principles of interaction between biomaterials and living systems. |
| Understands the basic possibilities of modifying the properties of biomaterials. |
| Understands the basic possibilities of modifying the properties of biomaterials. |
| Knows the basic technologies used in the production of biomaterials. |
| Knows the basic technologies used in the production of biomaterials. |
| Knows the process of safety testing of materials. |
| Knows the process of safety testing of materials. |
| Skills |
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| Plan a baseline scheme for biosafety testing of materials. |
| Plan a baseline scheme for biosafety testing of materials. |
| Plan experiments to determine the suitability of materials for a specific application. |
| Plan experiments to determine the suitability of materials for a specific application. |
| Evaluate the suitability of basic biomaterial preparation technologies for a specific application. |
| Evaluate the suitability of basic biomaterial preparation technologies for a specific application. |
| teaching methods |
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| Knowledge |
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| Lecturing |
| Lecturing |
| Dialogic (Discussion, conversation, brainstorming) |
| Dialogic (Discussion, conversation, brainstorming) |
| Skills |
|---|
| Individual work of students |
| Individual work of students |
| Practice exercises |
| Practice exercises |
| assessment methods |
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| Knowledge |
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| Oral examination |
| Analysis of educational material |
| Analysis of educational material |
| Grade (Using a grade system) |
| Grade (Using a grade system) |
| Oral examination |
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Recommended literature
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CHEN, Q., THOUAS, G. Biomaterials: A Basic Introduction. Boca Raton: CRC Press, 2015. ISBN 978-1-4822-2769-7.
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LANZA, R.P., LANGER, R.S., VACANTI, J. Principles of Tissue Engineering. 4th Ed.. Amsterdam: Elsevier, 2014. ISBN 978-0-12-398358-9.
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NEČAS, O. Obecná biologie pro lékařské fakulty. 2000. ISBN 8086022463.
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RATNER, B.D. Biomaterials science: an introduction to materials in medicine. 3rd ed.. Amsterdam: Elsevier/Academic Press, 2013. ISBN 978-0-12-374626-9.
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RUYS, A.J. Biomimetic Biomaterials: Structure and Applications. Oxford: Woodhead Publishing, 2013. ISBN 978-0-85709-416-2.
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Snustad, D. Peter. Genetika. Vyd. 1. Brno : Masarykova univerzita, 2009. ISBN 978-80-210-4852-2.
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