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Lecturer(s)
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Humpolíček Petr, prof. Ing. Ph.D.
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Course content
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1. Genome, proteome, transcriptome, metabolome. 2. Epigenetics. 3. Genomic imprinting. 4. RNA interference. 5. Pharmacogenomics. 6. Microbiome. 7. Technology in omic sciences I. 8. Technology in omic sciences II. 9. Reconstituted in vitro tissues (skin corrosion, skin irritation, eye irritation). 10. Methods of evaluation of biological properties (in vitro, in vivo, in silico), alternative methods of testing, ISO 10 993. 11. Skin irritation, sensitization. 12. Phototoxicity, mutagenicity, reproductive and developmental toxicity. 13. In vivo tests, methods, models and ethical aspects. 14. Development and testing of drugs.
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Learning activities and teaching methods
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- Preparation for examination
- 150 hours per semester
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| learning outcomes |
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| Knowledge |
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| The student understands the procedures for testing biological properties of materials. |
| The student understands the procedures for testing biological properties of materials. |
| The student can describe the principles of methods used in the study of biological properties of materials. |
| The student can describe the principles of methods used in the study of biological properties of materials. |
| The student understands the nature of alternative methods of testing biological properties. |
| The student understands the nature of alternative methods of testing biological properties. |
| Skills |
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| The student can critically evaluate a plan of experiments to determine the biological properties of materials. |
| The student can critically evaluate a plan of experiments to determine the biological properties of materials. |
| The student can prepare a biocompatibility test design |
| The student can prepare a biocompatibility test design |
| The student masters basic techniques of working in the cell biology laboratory. |
| The student masters basic techniques of working in the cell biology laboratory. |
| The student can perform and evaluate selected biocompatibility tests |
| The student can perform and evaluate selected biocompatibility tests |
| teaching methods |
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| Knowledge |
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| Lecturing |
| Lecturing |
| Dialogic (Discussion, conversation, brainstorming) |
| Dialogic (Discussion, conversation, brainstorming) |
| Skills |
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| Simple experiments |
| Simple experiments |
| Individual work of students |
| Individual work of students |
| assessment methods |
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| Knowledge |
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| Composite examination (Written part + oral part) |
| Composite examination (Written part + oral part) |
| Grade (Using a grade system) |
| Grade (Using a grade system) |
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Recommended literature
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ALBERTS B. et al. Molecular Biology of the Cell. Garland Science, New York, 2002.
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ROSYPAL, S. Nový přehled biologie. Praha: Scientia., 2003.
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SAHU, S.C, CASCIANO, D.A. Nanotoxicity: From in vivo and in vitro Models to Health Risks. Oxford: Wiley-Blackwell, 2009. ISBN 978-0-47074-137-5.
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SNUSTAD, D.P., SIMMONS, M.J., RELICHOVÁ, J. et al. Genetika. Brno: Nakladatelství Masarykovy univerzity., 2009.
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Vymětalová. Biologie pro biomedicínské inženýrství. ISBN 978 80 01 05.
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