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Lecturer(s)
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Kadlečková Markéta, Ing. Ph.D.
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Kocourková Karolína, Ing. Ph.D.
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Vícha Jan, Mgr. Ph.D.
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Víchová Zdenka, doc. Ing. Ph.D.
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Humpolíček Petr, prof. Ing. Ph.D.
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Course content
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1. Definition of biomaterials; natural and synthetic biomaterials. 2. Principle of biomimetics; biocompatibility; bio-inspired materials, tissue engineering, regenerative medicine. 3. Types, chemical structure and physical properties of biomaterials. Description of basic building units and the influence of their arrangement on the resulting properties of biomaterials. 4. Biomaterial interaction with cells, tissues and immune system. 5. Interactions of biomaterials with extracellular matter. 6. Biomaterial interactions with blood and proteins. 7. Surface properties of biomaterials. 8. Modification of surface properties. 9. Mechanical and electrical properties of biomaterials. 10. Biodegradation of biomaterials. 11. Fundamentals of medical device production technologies. 12. Key problems in biomaterial development. 13. Bioreactors and Lab on the chip. 14. In vivo and clinical case studies.
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Learning activities and teaching methods
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Individual work of students
- Preparation for examination
- 120 hours per semester
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| learning outcomes |
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| Knowledge |
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| Knows the basic types of biomaterials and distinguish their suitability for different applications. |
| Knows the basic types of biomaterials and distinguish their suitability for different applications. |
| Understands basic and advanced mechanisms of cell-biomaterial interactions. |
| Understands basic and advanced mechanisms of cell-biomaterial interactions. |
| Understands basic and advanced mechanisms of immune system interaction with biomaterials. |
| Understands basic and advanced mechanisms of immune system interaction with biomaterials. |
| Knows the technologies for the preparation of biomaterials. |
| Knows the technologies for the preparation of biomaterials. |
| Skills |
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| Can plan advanced biosafety experiments. |
| Can plan advanced biosafety experiments. |
| Can plan the characterisation of physicochemical properties. |
| Can plan the characterisation of physicochemical properties. |
| Can analyse and evaluate experiments. |
| Can analyse and evaluate experiments. |
| Can select an appropriate procedure for the preparation of biomaterials. |
| Can select an appropriate procedure for the preparation of biomaterials. |
| teaching methods |
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| Knowledge |
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| Lecturing |
| Lecturing |
| Dialogic (Discussion, conversation, brainstorming) |
| Dialogic (Discussion, conversation, brainstorming) |
| Skills |
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| Individual work of students |
| Individual work of students |
| Analysis of a presentation |
| Analysis of a presentation |
| assessment methods |
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| Knowledge |
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| Analysis of educational material |
| Analysis of educational material |
| Grade (Using a grade system) |
| Grade (Using a grade system) |
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Recommended literature
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CHEN, Q., THOUAS, G. Biomaterials: A Basic Introduction. Boca Raton: CRC Press, 2015. ISBN 978-1-4822-2769-7.
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LANZA, R.P., LANGER, R.S., VACANTI, J. Principles of Tissue Engineering. 4th Ed.. Amsterdam: Elsevier, 2014. ISBN 978-0-12-398358-9.
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Nečas, O. Obecná biologie pro lékařské fakulty. 2000.
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RUYS, A.J. Biomimetic Biomaterials: Structure and Applications. Oxford: Woodhead Publishing, 2013. ISBN 978-0-85709-416-2.
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SNUSTAD, D.P., SIMMONS, M.J., RELICHOVÁ, J. et al. Genetika. Brno: Masarykova univerzita, 2009.
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