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Lecturer(s)
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Koutný Marek, prof. Mgr. Ph.D.
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Course content
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1. Biochemistry, applications of biochemistry, the composition of living systems, interactions between molecules, basic energetic principles of living organisms. 2. Amino acids, properties of amino acids, peptide bond, protein, protein folding, description of 3D structure of proteins. 3. Enzymes, composition, cofactors, the principles of catalytic function, specificity, enzyme activity, basic enzyme kinetics, affecting the catalytic activity, regulation of activity, enzyme nomenclature, sources and use. 4. Vitamins. 5. Nucleotides, nucleic acids, structure, coding and structure of genetic information, expression of genetic information. 6. Lipids, properties, classification, nomenclature, biological membrane transport. 7. Carbohydrates, polysaccharides, structure, function, optical isomerism, formulas, properties, classification. 8. Bioenergetics, ATP and other energy-rich compounds, energy fixation. 9. Glycolysis, anaerobic metabolism, gluconeogenesis. 10. Lipid catabolism, beta-oxidation of fatty acids, fatty acid synthesis. 11. Citric acid cycle and functions, relationship to other metabolic processes, principles of metabolism regulation. 12. Respiratory chain, ATP synthesis on the membrane, alternative respiration. 13. Nitrogen metabolism. 14. Revision of metabolic survey, relationships of individual organs and tissues to the biochemical processes described.
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Learning activities and teaching methods
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Dialogic (Discussion, conversation, brainstorming), Individual work of students
- Preparation for examination
- 50 hours per semester
- Participation in classes
- 16 hours per semester
- Preparation for examination
- 30 hours per semester
- Home preparation for classes
- 40 hours per semester
- Preparation for course credit
- 34 hours per semester
- Participation in classes
- 56 hours per semester
- Preparation for course credit
- 34 hours per semester
- Preparation for examination
- 30 hours per semester
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| prerequisite |
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| Knowledge |
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| Knowledge of organic chemistry. |
| Knowledge of organic chemistry. |
| learning outcomes |
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| has deeper understanding mainly in the area of interest corresponding to the theme of doctoral thesis. |
| has deeper understanding mainly in the area of interest corresponding to the theme of doctoral thesis. |
| knows structures and properties of basic biomolecules. |
| knows structures and properties of basic biomolecules. |
| knows principles of function of biomolecules and their relationship to structure. |
| knows principles of function of biomolecules and their relationship to structure. |
| knows processes and principles of the central dogma of biomolecule synthesis. |
| knows processes and principles of the central dogma of biomolecule synthesis. |
| knows basic catabolic and synthetic metabolic pathways. |
| knows basic catabolic and synthetic metabolic pathways. |
| knows electron transport chain and ATP synthesis at the mitochondrial membrane. |
| knows electron transport chain and ATP synthesis at the mitochondrial membrane. |
| Skills |
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| knows to estimate and describe chemical properties based on structure. |
| knows to estimate and describe chemical properties based on structure. |
| knows to orient in the notation of metabolic pathways. |
| knows to orient in the notation of metabolic pathways. |
| knows to analyze the enzymatic processes using the MM equation. |
| knows to analyze the enzymatic processes using the MM equation. |
| knows to analyze the metabolic processes, type of reactions |
| knows to analyze the metabolic processes, type of reactions |
| teaching methods |
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| Knowledge |
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| Individual work of students |
| Individual work of students |
| Dialogic (Discussion, conversation, brainstorming) |
| Dialogic (Discussion, conversation, brainstorming) |
| Monologic (Exposition, lecture, briefing) |
| Monologic (Exposition, lecture, briefing) |
| Methods for working with texts (Textbook, book) |
| Methods for working with texts (Textbook, book) |
| Skills |
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| Individual work of students |
| Individual work of students |
| Dialogic (Discussion, conversation, brainstorming) |
| Dialogic (Discussion, conversation, brainstorming) |
| Practice exercises |
| Practice exercises |
| assessment methods |
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| Knowledge |
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| Conversation |
| Oral examination |
| Oral examination |
| Conversation |
| Written examination |
| Written examination |
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Recommended literature
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ALBERTS, B., JOHNSON, A., LEWIS, J., RAFF, M., ROBERTS, K., WATSON, J., D. Molecular Biology of the Cell. Garland publishing, 1999.
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GARRETT, H., R. A GRISHAM, C., M. Biochemistry. Saunders colledge publishing, 1995.
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GARRETT, H., R. Molecular aspect of cell biology. Saunders colledge publishing, 1995.
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KARLSON, P., GEROK, W., GROSS, W. Pathobiochemie. Academia, 1987.
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KODÍČEK,M., VALENTOVÁ,O., HYNEK,R. Biochemie: chemický pohled na biologický svět. Praha: VŠCHTv Praze, 2015. ISBN 978-80-7080-927-3.
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LEHNINGER A., NELSON D.L., YOUNG P. Principles of Biochemistry. W.H. Freeman & Company, 2007.
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MURRAY,R.K. Harperova ilustrovaná biochemie,5. české vyd., 1. v nakl. Galén. Praha: Galén, 2012. ISBN 978-80-7262-907-7.
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Nelson, David L. Lehninger principles of biochemistry. 5th ed. New York : W.H. Freeman, 2008. ISBN 978-0-7167-7108-1.
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POTÁČEK, M. Organická chemie pro biology. Vydavatelství Masarykovy university, 1995.
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SOFROVA, D. A KOL. Biochemie - Základní kurz. Karolinum, 1993.
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ŠÍPAL, Z. a kol. Biochemie. Praha : SPN, 1992. ISBN 80-04-21736-2.
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ŠÍPAL Z. a kol. Biochemie. SPN. Praha, 1992. ISBN 80-0421736-2.
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