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Lecturer(s)
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Jančová Petra, Mgr. Ph.D.
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Course content
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1. Introduction to general toxicology (basic terms, definitions, division of toxicology). 2. Fate of foreign substances in the organism (absorption, distribution). 3. Fate of foreign substances in the organism (biotransformation, excretion). 4. General principles of classification, diagnosis and therapy of poisoning (elimination of xenobiotics from the body; antidotes). 5. Genetic toxicology (carcinogens, mutagens, teratogens). 6. Experimental toxicology (animal tests, acute and chronic toxicity tests, carcinogenicity tests, mutagenicity, kinetic studies, biological exposure tests, epidemiological studies). Predictive toxicology (QSAR). 7. Special toxicology of selected inorganic substances (elements of main and secondary subgroups and their toxicologically important compounds). 8. Radioactive substances (selected radionuclides, biological effects of radiation). 9. Special toxicology of selected organic substances (hydrocarbons, alcohols, phenols, ethers, carbonyl compounds, carboxylic acids, esters of organic and inorganic acids, nitro and amino compounds, polycyclic aromatic hydrocarbons, dioxins, polychlorinated biphenyls, pesticides, polybrominated flame retardants). 10. Toxicology of narcotic and psychotropic substances. 11. Natural poisons (plant, animal, bacterial, toxins of molds and fungi). 12. Military toxicology (combat poisons, non-lethal chemical weapons, bioterrorism). 13. Analytical toxicology (drug tests, determination of alcohol in the body). 14. Legislation and work with poisons and other pollutants.
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Learning activities and teaching methods
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Lecturing
- Participation in classes
- 42 hours per semester
- Term paper
- 20 hours per semester
- Preparation for examination
- 28 hours per semester
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| prerequisite |
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| Knowledge |
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| Knowledge of inorganic and organic chemistry and basics of human biology. |
| Knowledge of inorganic and organic chemistry and basics of human biology. |
| learning outcomes |
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| list and describe the different phases of toxicokinetics |
| list and describe the different phases of toxicokinetics |
| characterise the mechanisms of action of toxic substances |
| characterise the mechanisms of action of toxic substances |
| describe the effects of toxicologically important inorganic compounds |
| describe the effects of toxicologically important inorganic compounds |
| characterise the major groups of organic toxicants (in particular POPs - pesticides, PAHs, PCBs, PCDD/Fs) and describe their effects |
| characterise the major groups of organic toxicants (in particular POPs - pesticides, PAHs, PCBs, PCDD/Fs) and describe their effects |
| describe the test toxicity (in vitro, in vivo, in silico) |
| describe the test toxicity (in vitro, in vivo, in silico) |
| Skills |
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| define the toxic effects of compounds of toxicological significance |
| define the toxic effects of compounds of toxicological significance |
| teaching methods |
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| Knowledge |
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| Lecturing |
| Lecturing |
| Methods for working with texts (Textbook, book) |
| Methods for working with texts (Textbook, book) |
| Skills |
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| Dialogic (Discussion, conversation, brainstorming) |
| Dialogic (Discussion, conversation, brainstorming) |
| assessment methods |
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| Knowledge |
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| Written examination |
| Written examination |
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Recommended literature
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Anděl, Petr. Ekotoxikologie, bioindikace a biomonitoring. Vyd. 1. Liberec : Evernia, 2011. ISBN 978-80-903787-9-7.
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Hirt, M. Toxikologie a jiné laboratorní metody ve forenzní praxi. Brno, 2011. ISBN 978-80-210-5477-6.
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Horák J., Linhart I., Klusoň P. Úvod do toxikologie a ekologie pro chemiky. Praha, 2007. ISBN 978-80-7080-548-0.
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Klaassen, C.D. Casarett & Doull's Toxicology: The Basic Science of Poisons, Seventh Edition. McGraw-Hill Professional. 2008.
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LINHART, I. Toxikologie: Interakce škodlivých látek s živými organismy, jejich mechanismy, projevy a důsledky. VŠCHT Praha. 2022.
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Patočka J. Vojenská toxikologie. Praha, 2004. ISBN 80-247-0608-3.
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Prokeš J. Základy toxikologie. Praha, 2005. ISBN 80-7262-301-X.
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