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Lecturer(s)
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Koutný Marek, prof. Mgr. Ph.D.
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Course content
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- Biochemistry, applications of biochemistry, the composition of living systems, interactions between molecules, the basic principles of the energetics of living organisms. - Amino acids, properties of amino acids, peptide bond, protein, protein folding, description of the 3D structure of proteins. - Enzymes, composition, cofactors, the principles of catalytic function, specificity, enzyme activity, basic enzyme kinetics, affecting the catalytic activity, regulation of activity, enzyme nomenclature, sources and use. - Vitamins. - Nucleotides, nucleic acids, structure, coding and structure of genetic information, expression of genetic information. - Lipids, properties, classification, nomenclature, biological membrane transport. - Carbohydrates, polysaccharides, structure, function, optical isomerism, formulas, properties, classification. - Bioenergetics, ATP and other energy-rich compounds, energy fixation. - Glycolysis, anaerobic metabolism, gluconeogenesis. - Lipid catabolism, beta-oxidation of fatty acids, fatty acid synthesis. - Citric acid cycle and functions, relationship to other metabolic processes, principles of regulation of metabolism. - Respiratory chain, ATP synthesis on the membrane, alternative respiration. - Nitrogen metabolism. - Recap metabolic survey, the relationship of individual organs and tissues for the biochemical processes described.
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Learning activities and teaching methods
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Monologic (Exposition, lecture, briefing)
- Preparation for examination
- 120 hours per semester
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| prerequisite |
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| Knowledge |
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| Knowledge of organic chemistry. |
| Knowledge of organic chemistry. |
| learning outcomes |
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| knows structures and properties of basic biomolecules. |
| knows structures and properties of basic biomolecules. |
| knows principles of function of biomolecules and their relationship to structure. |
| knows principles of function of biomolecules and their relationship to structure. |
| knows processes and principles of the central dogma of biomolecule synthesis. |
| knows processes and principles of the central dogma of biomolecule synthesis. |
| knows basic catabolic and synthetic metabolic pathways. |
| knows basic catabolic and synthetic metabolic pathways. |
| knows electron transport chain and ATP synthesis at the mitochondrial membrane. |
| knows electron transport chain and ATP synthesis at the mitochondrial membrane. |
| Skills |
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| knows to estimate and describe chemical properties based on structure. |
| knows to estimate and describe chemical properties based on structure. |
| knows to orient in the notation of metabolic pathways. |
| knows to orient in the notation of metabolic pathways. |
| knows to analyze the enzymatic processes using the MM equation. |
| knows to analyze the enzymatic processes using the MM equation. |
| knows to analyze the metabolic processes, type of reactions |
| knows to analyze the metabolic processes, type of reactions |
| teaching methods |
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| Knowledge |
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| Monologic (Exposition, lecture, briefing) |
| Monologic (Exposition, lecture, briefing) |
| Methods for working with texts (Textbook, book) |
| Methods for working with texts (Textbook, book) |
| Skills |
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| Dialogic (Discussion, conversation, brainstorming) |
| Dialogic (Discussion, conversation, brainstorming) |
| Practice exercises |
| Practice exercises |
| assessment methods |
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| Knowledge |
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| Oral examination |
| Oral examination |
| Written examination |
| Written examination |
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Recommended literature
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LEHNINGER A., NELSON D.L., YOUNG P. Principles of Biochemistry. W.H. Freeman & Company , 2007.
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ŠÍPAL Z. a kol. Biochemie. SPN. Praha , 1992. ISBN ISBN 80-0421736-2.
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