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Lecturer(s)
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Kafka Stanislav, doc. Ing. CSc.
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Course content
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- The principle of action of non-narcotic analgesics, examples of substances used therapeutically. - Opium alkaloids - their natural source, influence of effectiveness by the introduction and changes of substitution of the basic skeleton. - Neurotransmitters, their chemical structures and functions in the organism. - Barbiturates and thiobarbiturates - chemical structure, synthesis, biological effects and therapeutic use. - Compounds with a 3-phenylpropan-2-amine skeleton. - Compounds with a psychodysleptic effect. - Benzodiazepines - structure, biological effects and therapeutic use. - Tropane alkaloids - occurrence, effects and use. - Acetylcholine, acetylcholinesterase (AChE) inhibitors and AChE reactivators. - Disinfectants, antiseptics and germicides - examples of substances used. - Antibiotics - definition, examples of groups of antibiotics. - Alkaloids derived from tryptophan. - Nucleic acid bases - structures, complementarity of bases, formation of nucleosides, nucleotides, other compounds with purine and pyrimidine skeletons. - Occurrence in nature, syntheses and biological activity of 5-membered heterocycles. - Occurrence in nature, syntheses and biological activity of 6-membered heterocycles - Basic groups of drugs affecting the vegetative nervous system according to the nature of the effect.
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Learning activities and teaching methods
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- Preparation for examination
- 50 hours per semester
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| teaching methods |
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| Knowledge |
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| Individual work of students |
| Individual work of students |
| Skills |
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| Individual work of students |
| Individual work of students |
| assessment methods |
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| Knowledge |
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| Oral examination |
| Oral examination |
| Grade (Using a grade system) |
| Grade (Using a grade system) |
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Recommended literature
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Antošová, Z. et al. Farmaceutický encyklopedický slovník. Praha: VŠChT, 2014. ISBN 978-80-7080-876-4.
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Drabina, P. Bioorganická chemie. Pardubice: Univerzita Pardubice, 2020. ISBN 978-80-7560-316-6.
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Hampl, F., Rádl S., Paleček, J. Farmakochemie (3. vydání). Praha: VŠChT, 2015. ISBN 978-80-7080-875-7.
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Kodíček, M., Valentová, O., Hynek, R.. Biochemie - chemický pohled na biologický svět (3. vydání). Praha: VŠChT, 2022. ISBN 978-80-7592-124-6.
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Ménová, P., Hampl, F. Základy farmakochemie (1. vydání). Praha: VŠChT, 2022. ISBN 978-80-7592-119-2.
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Nogrady, T. Medicinal chemistry : a molecular and biochemical approach. New York: Oxford University, 2005. ISBN 0-19-510456-0.
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Patrick, G. L., Spencer, J. An introduction to medicinal chemistry. Oxford : Oxford University Press, 2009. ISBN 978-0-19-923447-9.
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Staněk, J. Alkaloidy. Praha: Nakladatelství ČSAV, 1957.
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10. Prouza, V., Zýka J. Bioorganická chemie přírodních látek (1. vydání). Praha: VŠChT, 2022. ISBN 978-80-7592-148-2.
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