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Lecturer(s)
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Klásek Antonín, prof. Ing. DrSc.
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Course content
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- Material composition of living systems, an overview of the natural macromolecules and low molecular weight substances. - Conformation and configuration. Structure levels of natural macromolecules, intramolecular and intermolecular non-covalent bonds. - Metabolism in living systems - catabolism and anabolism. - Energy conversion - transfer, storage and energy utilisation. - Amino acids and peptides. Spatial structure and function of proteins, their metabolism. - Enzymes - classification, activity, mechanism of action, enzyme kinetics, activation and inhibition. - Nucleic acids - classification, composition, conformation. Transmission of information in living systems, protein biosynthesis. - Natural pigments. - Oxygen metabolism, respiratory chain and oxidative phosphorylation. - Tricarboxylic acid cycle, photosynthesis and nitrogen assimilation. - Saccharides - monosaccharides, glycosides, polysaccharides, carbohydrate metabolism and its regulation. - Lipids and isoprenoids - structure, function and metabolism. - Hormones and vitamins - classification and their effects. - Alkaloids - occurrence, an overview of the most common structure types and biological effects.
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Learning activities and teaching methods
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Methods for working with texts (Textbook, book), Individual work of students
- Preparation for examination
- 80 hours per semester
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| prerequisite |
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| Knowledge |
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| The knowledge of organic chemisty. |
| The knowledge of organic chemisty. |
| learning outcomes |
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| structure and function of basic biomolecules |
| structure and function of basic biomolecules |
| stereochemistry of natural compounds |
| stereochemistry of natural compounds |
| types of biopolymers, their importance and orders of their structure |
| types of biopolymers, their importance and orders of their structure |
| substance transformations in organisms |
| substance transformations in organisms |
| occurrence of individual types of natural substances |
| occurrence of individual types of natural substances |
| Skills |
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| to classify natural substances into individual structural classes |
| to classify natural substances into individual structural classes |
| to describe the structure, properties and reactions of individual classes of natural substances and their biogenesis |
| to describe the structure, properties and reactions of individual classes of natural substances and their biogenesis |
| to explain the importance of non-covalent interactions for the structure and function of biopolymers |
| to explain the importance of non-covalent interactions for the structure and function of biopolymers |
| to describe the principles of transfer, storage and use of energy in the organism |
| to describe the principles of transfer, storage and use of energy in the organism |
| to describe the principles of basic oxidation-reduction processes in organisms |
| to describe the principles of basic oxidation-reduction processes in organisms |
| teaching methods |
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| Knowledge |
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| Individual work of students |
| Methods for working with texts (Textbook, book) |
| Methods for working with texts (Textbook, book) |
| Individual work of students |
| Skills |
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| Individual work of students |
| Individual work of students |
| Practice exercises |
| Practice exercises |
| assessment methods |
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| Knowledge |
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| Oral examination |
| Oral examination |
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Recommended literature
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Fukal, L. a kol. Od biomolekul k buňce. ÚOCHB ČSAV, Praha 1992. ISBN nemá.
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Introduction to Organic Biochemistry. http//www.ebook30.com/science/chemistry/121955. http//www.ebook30.com/science/chemistry/121955.
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Klásek, A. Biopolymery. Skripta FT, SNTL, Praha 1980. ISBN nemá.
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Klásek, A. Organická chemie. UTB ve Zlíně, Zlín 2006. ISBN 80-7318-483-4.
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Kolektiv. Od biomolekul k buňce. 19.sv. "Org. chemie", ÚOCHB ČSAV, Praha 1992. ISBN nemá.
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McMurry, E.J. Organic Chemistry. A Biological Approach. Brooks Cole, 2006. ISBN 0-495-01525-3.
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McMurry, J. Organic chemistry. Broks/Cole Publish. Co., Pacific Grove, 1996. ISBN 0-534-23832-7.
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McMurry, J. Organická chemie. Praha, 2015.
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Medicinal Chemistry of Bioactive Natural Products. http://ebooks.ebookmall.com.
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Moravcová, J. Biologicky aktivní přírodní látky. http://www.vscht.cz/lam/new/bapl2003-01.pdf.
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Natural Product Chemistry. http://www.pdfgeni.com/book.
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Přírodní látky - homepage. http://www.biotox.cz/naturstoff/chemie/default.html.
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Vodrážka, Zdeněk. Bioorganická chemie. 1. vyd. Praha : SNTL, 1991. ISBN 80-03-00547-7.
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Voet, D., Voetová, J.G. Biochemie. Viktoria Publ. , Praha 1995. ISBN 80-85-605-44-9.
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Zubay, G. Biochemistry. Wm. C. Brown Publishers, London 1998. ISBN 0-697-21900-3.
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