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Lecturer(s)
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Vícha Robert, doc. Mgr. Ph.D.
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Course content
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1) Basic concepts of supramolecular chemistry. 2) Basic thermodynamic principles (measurement of K, G, H, van't Hoff method). 3) Intermolecular interactions in supramolecular chemistry. Hydrogen bond, halogen bond, polar interaction (ion-ion, ion-dipole, dipole-dipole), ion-pi interaction, pi-pi interaction, dispersion London forces, hydrophobic effect. Lateral interaction. 4) Research methods - stoichiometry of the complex (Job's Plot vs. residual distribution in titration data). 5) Research methods - NMR, X-ray, MS, calorimetric methods, UV-Vis, electrochemical methods. 6) Multivalent ligands, multivalent host molecules. Competitive and cooperative effects. 7) Crown ethers and similar groups of macrocycles starting with valinomycin. 8) Cryptands and carcerands. 9) Anion receptors. 10) Basic cyclodextrins (alpha-CD, beta-CD, gamma-CD). 11) Cyclodextrins lower and higher. 12) Modified cyclodextrins: From Ronald Breslow to Matthieu Sollogoub. 13) Basic cucurbiturils (CB5, CB6, CB7, CB8, CB10). 14) Other glycoluril macrocycles (t-CBs, i-CBs, ns-CBc, preso-CBs). 15) Modified CBs. 16) Calixarenes, resorciarenes, octa acid. 17) Mechanically locked structures (rotaxanes, suitanes, catenanes, molecular knots, Borromeo rings). 18) Molecular machines: switches, motors. 19) Supramolecular catalysts. 20) Supramolecular relationships in living systems, supramolecular nature of vision and oxygen distribution (hemoglobin, myoglobin), allosteric inhibition/activation of enzymes.
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Learning activities and teaching methods
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- Preparation for examination
- 50 hours per semester
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| learning outcomes |
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| Knowledge |
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| Detailed knowledge of intermolecular interactions. |
| Detailed knowledge of intermolecular interactions. |
| A detailed overview of the main groups of macrocyclic receptors. |
| A detailed overview of the main groups of macrocyclic receptors. |
| Principles of construction of higher order complexes. |
| Principles of construction of higher order complexes. |
| Skills |
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| Analysis of experimental data with regard to stoichiometry and stability of complexes. |
| Analysis of experimental data with regard to stoichiometry and stability of complexes. |
| Estimation of mutual electronic and spatial complementarity of given host-guest pairs. |
| Estimation of mutual electronic and spatial complementarity of given host-guest pairs. |
| teaching methods |
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| Knowledge |
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| Individual work of students |
| Individual work of students |
| Methods for working with texts (Textbook, book) |
| Methods for working with texts (Textbook, book) |
| Skills |
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| Individual work of students |
| Individual work of students |
| Practice exercises |
| Practice exercises |
| assessment methods |
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| Knowledge |
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| Oral examination |
| Oral examination |
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Recommended literature
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CIFERRI, A. Supramolecular Polymers. Boca Raton: Taylor & Francis, 2005. ISBN 978-0-8247-2331-6.
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DIEDERICH, F., STANG, P.J., TYKWINSKI, R.R. Modern Supramolecular Chemistry. Weinheim: Wiley-VCH, 2008. ISBN 978-3-527-31826-1.
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DODZIUK, H. Cyclodextrins and their Complexes. Weinheim: Wiley-VCH, 2006. ISBN 9783527312801.
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KIM, K., KO, Z.H., SELVAPALAM, N. Cucurbiturils: Chemistry, Supramolecular Chemistry and Applications. Imperial College Press, 2014. ISBN 978-1-848-16408-6.
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KUBO, Y., NISHIYABU, R. White-Light Emissive Materials based on Dynamic Polymerization in Supramolecular Chemistry. Polymer 128, 257-275, 2017.
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LEHN, J.M. Supramolecular Chemistry: Concepts and Perspectives. Weinheim: Wiley-VCH, 1995. ISBN 9783527293124.
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LU, W., LE, X., ZHANG, J., HUANG, Y., CHEN, T. Supramolecular Shape Memory Hydrogels: A New Bridge between Stimuli-Responsive Polymers and Supramolecular Chemistry. Chemical Society Reviews 46(5), 1284-1294, 2017.
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SCHALLEY, C. Analytical Methods in Supramolecular Chemistry. Weinheim: Wiley-VCH, 2007. ISBN 9783527315055.
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SCHEIDER, H.J., YATSIMIRSKY, A. Principles and Methods in Supramolecular Chemistry. Chichester: John Wiley & Sons, Ltd., 2000. ISBN 0-417-97253-3.
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STEED, J.W., ATWOOD, J.L. Supramolecular Chemistry. Chichester: Wiley-VCH, 2009. ISBN 9780470512333.
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