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Lecturer(s)
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Klásek Antonín, prof. Ing. DrSc.
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Course content
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- Formation and characterisation of chemical bond, conformation and configuration, Fischer, Newman and Haworth projection, geometric isomerism, stereochemistry of cycles. - Symmetry of molecules, chiral elements, specification of molecular chirality, tautomerism. - Polarity of chemical bonds, inductive, mesomeric and steric effects, hyperconjugation, charge-transfer complexes. - Theory of transition state, kinetic and thermodynamic control of chemical reactions, solvation effect, methods of reaction mechanism determination. - Nucleophilic substitution in saturated systems - kinetics, effects of reactants structure and reaction conditions. - Electrophilic and radical substitution in saturated systems. - Electrophilic and nucleophilic in aromatic systems. - Mono- and bimolecular elimination reactions. - Nucleophilic, electrophilic and radical additions, aldolisation and related reactions. - Esterification and ester hydrolysis, reaction of enamines. - Molecular rearrangements of saturated and unsaturated systems, asymmetrical reactions. - Carbohydrates - stereochemistry and reactions, lipids. - Peptides and proteins - formation and properties. - Nucleic acids - the composition and operation. - Photochemical reactions - electron transitions, decomposition of the excited state, transfer of energy. - Photochemistry of selected organic compounds, photochemical oxidations with singlet and triplet oxygen. - Reaction intermediates - carbocations, carbanions, carbenes, nitrenes, arines. - The formation, identification and reactivity of free radicals. - Elemental and complex reactions of radicals, branched and unbranched chain reactions, free radicals in biological systems. - Nomenclatury of heterocycles, preparations and reactions of basic five- and six membered heterocycles and their benzodeivatives, pyrimidine and its derivatives, triazine, purines.
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Learning activities and teaching methods
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Methods for working with texts (Textbook, book), Individual work of students
- Preparation for examination
- 80 hours per semester
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| prerequisite |
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| Knowledge |
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| Knowledge of organic chemistry (chemistry-oriented master degree level). |
| Knowledge of organic chemistry (chemistry-oriented master degree level). |
| learning outcomes |
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| stereochemical concepts and expressing the spatial arrangement of molecules in the names of compounds |
| stereochemical concepts and expressing the spatial arrangement of molecules in the names of compounds |
| mechanisms of homolytic and heterolytic reactions of organic compounds |
| mechanisms of homolytic and heterolytic reactions of organic compounds |
| mechanisms of pericyclic reactions |
| mechanisms of pericyclic reactions |
| the principle of photochemical reactions |
| the principle of photochemical reactions |
| structures of carbohydrates, lipids, peptides and nucleic acids |
| structures of carbohydrates, lipids, peptides and nucleic acids |
| nomenclature, reactivity and syntheses of monocyclic heterocycles with oxygen, nitrogen and sulfur atoms and their benzologs |
| nomenclature, reactivity and syntheses of monocyclic heterocycles with oxygen, nitrogen and sulfur atoms and their benzologs |
| Skills |
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| to draw formulas expressing the constitution, configuration and conformation of molecules according to the names of the compounds |
| to draw formulas expressing the constitution, configuration and conformation of molecules according to the names of the compounds |
| to draw diagrams showing reaction mechanisms |
| to draw diagrams showing reaction mechanisms |
| to explain the methods of determining the reaction mechanism |
| to explain the methods of determining the reaction mechanism |
| to assume the possible course of chemical reactions of organic compounds according to their structure and reaction conditions |
| to assume the possible course of chemical reactions of organic compounds according to their structure and reaction conditions |
| to propose possibilities for the preparation of compounds based on knowledge of reactions leading to certain types of compounds |
| to propose possibilities for the preparation of compounds based on knowledge of reactions leading to certain types of compounds |
| to explain the possibilities of carrying out asymmetric reactions with giving of examples |
| to explain the possibilities of carrying out asymmetric reactions with giving of examples |
| teaching methods |
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| Knowledge |
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| Methods for working with texts (Textbook, book) |
| Individual work of students |
| Individual work of students |
| Methods for working with texts (Textbook, book) |
| Skills |
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| Individual work of students |
| Individual work of students |
| Practice exercises |
| Practice exercises |
| assessment methods |
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| Knowledge |
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| Oral examination |
| Oral examination |
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Recommended literature
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CRANWELL, P.B., HARWOOD, L.M., MOODY, CH.J. Experimental Organic Chemistry. 3rd Ed. Hoboken: Wiley, 2017. ISBN 978-1-119-95238-1.
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ČERVINKA, O. a kol. Chemie organických sloučenin. Praha, SNTL, 1985.
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ČERVINKA, O., DĚDEK, V., FERLES, M. Organická chemie. Praha: Informatorium, 1991. ISBN 80-85427-03-6.
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JOULE, J.A., MILLS, K. Heterocyclic Chemistry at a Glance. 2nd Ed. Chichester: Wiley, 2013. ISBN 978-1-118-38020-8.
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Klásek, A. Organická chemie. Zlín: UTB, 2006.
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Kolektiv. Chemie organických sloučenin I a II. Praha: SNTL, 1985.
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LAZÁR, M. Chemické reakcie vol´ných radikálov. Bratislava: Alfa, 1983.
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McMURRY, J. Organic Chemistry. Brooks/Cole Publ. Co., 1966. ISBN 0-534-23832-7.
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McMURRY, J. Organická chemie. Praha, 2015. ISBN 978-80-7080-930-3.
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MORRIS, D.G. Stereochemistry. Cambridge: Royal Society of Chemistry, 2001.
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PANICO, R. a kol. Průvodce názvoslovím organických sloučenin podle IUPAC. Praha: Academia, 2000. ISBN 80-200-0724-5.
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TAYLOR, P. Mechanism and Synthesis. Cambridge: Royal Society of Chemistry, 2002.
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WADE, L.G., SIMEK, J.W. Organic Chemistry. (9th Edition). London: Pearson, 2016. ISBN 978-0321971371.
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