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Lecturer(s)
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Kafka Stanislav, doc. Ing. CSc.
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Course content
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1. Basic concepts and definitions, principles of interaction of organism and drugs, developmental stages of drugs. 2. Analgesics. 3. Central nervous system drugs - general anesthetics, sedatives and hypnotics. 4. Drugs of the central nervous system - psychopharmaceuticals, antiepileptics, anti-parkinson drugs and antimigraine preparations. 5. Drugs of the vegetative nervous system - adrenergics and antiadrenergics. 6. Drugs of the vegetative nervous system - cholinergics and anticholinergics. Myotropic spasmolytics. 7. Local anesthetics, myorelaxants, antitussives and expectorants. 8. Antiallergics and antihistamines. 9. Medicaments of circulatory system. 10. Medicaments of the digestive system. 11. Anti-infectious and anti-invasive substances. 12. Cytostatics. 13. Dermatology. 14. Methods of designing new drugs, good manufacturing practice.
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Learning activities and teaching methods
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- Participation in classes
- 42 hours per semester
- Home preparation for classes
- 16 hours per semester
- Preparation for examination
- 32 hours per semester
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| prerequisite |
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| Knowledge |
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| Knowledge of organic chemistry, methods of synthesis of organic substances. |
| Knowledge of organic chemistry, methods of synthesis of organic substances. |
| learning outcomes |
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| basic concepts from pharmacokinetics |
| basic concepts from pharmacokinetics |
| basic concepts from pharmacodynamics |
| basic concepts from pharmacodynamics |
| methods of developing new drugs |
| methods of developing new drugs |
| content and goals of individual phases of new drugs testing |
| content and goals of individual phases of new drugs testing |
| medicines lifecycle |
| medicines lifecycle |
| Skills |
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| explain basic concepts from the field of pharmacology |
| explain basic concepts from the field of pharmacology |
| characterize individual levels of testing potential new drugs |
| characterize individual levels of testing potential new drugs |
| explain the principles of the effects of individual therapeutic groups of drugs on the organism |
| explain the principles of the effects of individual therapeutic groups of drugs on the organism |
| draw the structural chemical formulas of selected most common drugs |
| draw the structural chemical formulas of selected most common drugs |
| describe the reaction schemes of the synthesis of selected most common drugs |
| describe the reaction schemes of the synthesis of selected most common drugs |
| teaching methods |
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| Knowledge |
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| Lecturing |
| Lecturing |
| Methods for working with texts (Textbook, book) |
| Methods for working with texts (Textbook, book) |
| Skills |
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| Monologic (Exposition, lecture, briefing) |
| Monologic (Exposition, lecture, briefing) |
| Dialogic (Discussion, conversation, brainstorming) |
| Dialogic (Discussion, conversation, brainstorming) |
| assessment methods |
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| Knowledge |
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| Didactic test |
| Didactic test |
| Written examination |
| Written examination |
| Grade (Using a grade system) |
| Grade (Using a grade system) |
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Recommended literature
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HAMPL, F., RÁDL, S., PALEČEK, J. Farmakochemie. Praha: VŠCHT, 2002. ISBN 80-7080-495-5.
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Hanika, J. Farmaceutické inženýrství. Praha: VŠCHT, 2013. ISBN 978-80-7080-859-7.
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KUCHAŘ, M. (Ed.). Farmaceutický encyklopedický slovník. Praha: VŠCHT, 2014. ISBN 978-80-7080-876-4.
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Ménová, P.; Hampl, F. Základy farmakochemie. VŠCHT Praha, 2022. ISBN 978-80-7592-119-2.
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PATRICK, G.L. An Introduction to Medicinal Chemistry. 4th Ed.. Oxford University Press, 2009. ISBN 978-0-19-923447-9.
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Rádl, S. Příběhy spojené s objevy nových léčiv. VŠCHT Praha, 2023. ISBN 978-80-7592-165-9.
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VOTAVA, M., SLÍVA, J. Farmakologie v kostce. Praha: Triton, 2021. ISBN 978-80-7553-893-2.
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WERMUTH, C.G. The Practice of Medicinal Chemistry. Amsterdam: Elsevier/Academic Press, 2008. ISBN 978-0-12-374194-3.
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