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Lecturer(s)
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Kafka Stanislav, doc. Ing. CSc.
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Course content
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1. Reduction of multiple bonds between carbon atoms, hydrogenolysis. 2. Reduction of functional groups with oxygen, nitrogen and sulfur atoms. 3. Oxidation of hydrocarbons. 4. Oxidation of hydrocarbon derivatives. 5. Introduction of halogen atoms into molecules - addition of hydrogen halides, halogens and hypohalogens to C = C, substitution of the hydrogen atom by a halogen atom. 6. Introduction of halogen atoms into molecules - substitution of hydroxyl group, oxygen atom in carbonyl group and metal atoms by halogen atoms, replacing a halogen atom with an atom of another halogen. 7. Nitration, nitrosation and sulfonation. 8. Alkylation and acylation of aromatic compounds. 9. Preparation of organometallic compounds, transformation and synthetic utilization especially of organomagnesium, organolithium and organo-zinc compounds. 10. Diazotization, diazonium substitution, coupling reactions, C-C bond formation. 11. Eliminations. 12. Knoevenagel reaction, P-ylides, Wittig reaction, Horner - Wadsworth - Emmons reaction. 13. Darzens reaction, S-ylides and their use in the preparation of oxirane derivatives. 14. Protecting groups in organic synthesis. Protection of hydroxyl, carbonyl, carboxyl and amino groups.
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Learning activities and teaching methods
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- Participation in classes
- 56 hours per semester
- Home preparation for classes
- 24 hours per semester
- Preparation for course credit
- 24 hours per semester
- Preparation for examination
- 16 hours per semester
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| prerequisite |
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| Knowledge |
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| Knowledge of organic chemistry. |
| Knowledge of organic chemistry. |
| learning outcomes |
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| methods of reduction and oxidation of organic compounds |
| methods of reduction and oxidation of organic compounds |
| methods of introduction of halogen atoms and nitrogen or sulfur containing groups into molecules of organic compounds |
| methods of introduction of halogen atoms and nitrogen or sulfur containing groups into molecules of organic compounds |
| use of elimination reactions in the syntheses of organic compounds |
| use of elimination reactions in the syntheses of organic compounds |
| methods of carbon chains building by means of alkylation and acylation reactions and with the use of P-ylides |
| methods of carbon chains building by means of alkylation and acylation reactions and with the use of P-ylides |
| possibilities of selective protection of functional groups in multi-step syntheses |
| possibilities of selective protection of functional groups in multi-step syntheses |
| Skills |
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| to propose a method for carrying out a certain type of chemical transformation of the starting compound |
| to propose a method for carrying out a certain type of chemical transformation of the starting compound |
| to propose a method of selective carrying out of the reduction of a certain group beside other reducible groups in the molecule |
| to propose a method of selective carrying out of the reduction of a certain group beside other reducible groups in the molecule |
| to propose a method of selectively carrying out of the oxidation of a certain group beside other oxidizable groups in the molecule |
| to propose a method of selectively carrying out of the oxidation of a certain group beside other oxidizable groups in the molecule |
| to assess the suitability of various reagents used for a given type of substrate conversion for application to a particular substrate |
| to assess the suitability of various reagents used for a given type of substrate conversion for application to a particular substrate |
| to assess the possibilities of influencing the given transformation by the reaction conditions |
| to assess the possibilities of influencing the given transformation by the reaction conditions |
| teaching methods |
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| Knowledge |
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| Lecturing |
| Lecturing |
| Dialogic (Discussion, conversation, brainstorming) |
| Dialogic (Discussion, conversation, brainstorming) |
| Skills |
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| Practice exercises |
| Practice exercises |
| assessment methods |
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| Knowledge |
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| Didactic test |
| Didactic test |
| Oral examination |
| Oral examination |
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Recommended literature
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Carey, Francis A. Advanced organic chemistry. New York : Plenum Press, 1977. ISBN 0-306-35116-1.
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McMurry, J. Organická chemie. Brno: VUTIUM, 2007.
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McMurry, J. Organická chemie. Praha, 2015. ISBN 978-80-7080-930-3.
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McMurry, J. Organická chemie. Praha, 2015. ISBN 978-80-7080-930-3.
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SVOBODA, J. Organická syntéza. VŠCHT Praha, 2017. ISBN 978-80-7080-990-7.
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SVOBODA, J. Sbírka příkladů z organické syntézy I. Praha: VŠCHT, 2000. ISBN 978-80-7080-386-8.
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