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Lecturer(s)
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Kafka Stanislav, doc. Ing. CSc.
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Course content
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- Material composition of living systems, overview of types of natural macromolecules and low molecular weight substances. Conformation and configuration. - Levels of the structure of natural macromolecules, intramolecular and intermolecular non-covalent bonds. - Substance transformations in living systems - catabolism and anabolism. Energy transformations - transmission, storage and extraction of energy. - Amino acids and peptides. - Spatial structure and function of proteins, their metabolism. - Enzymes - distribution, activity, mechanism of action, enzyme kinetics, activation and inhibition. - Nucleic acids - distribution, composition, conformation. - Information transfer in living systems, protein biosynthesis. - Natural dyes. - Oxygen metabolism, respiratory chain and oxidative phosphorylation. - Cycle of tricarboxylic acids, photosynthesis and nitrogen assimilation. - Carbohydrates - monosaccharides, glycosides, polysaccharides, carbohydrate metabolism and its regulation. - Lipids and isoprenoids - structure, function, metabolism. - Hormones and vitamins - division, effect. Processes on biomembranes.
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Learning activities and teaching methods
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Lecturing, Practice exercises
- Preparation for examination
- 90 hours per semester
- Preparation for examination
- 90 hours per semester
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| prerequisite |
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| Knowledge |
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| Znalosti organické chemie. |
| Znalosti organické chemie. |
| learning outcomes |
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| structure and function of biomolecules |
| structure and function of biomolecules |
| principles and reaction mechanisms of biochemical processes |
| principles and reaction mechanisms of biochemical processes |
| chemical synthesis of some biomolecules, including chiral ones with an excess of one of the enantiomers |
| chemical synthesis of some biomolecules, including chiral ones with an excess of one of the enantiomers |
| use of biocatalysis |
| use of biocatalysis |
| basic knowledge about transport events on biological membranes |
| basic knowledge about transport events on biological membranes |
| Skills |
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| describe the basic catabolic reactions leading to energy production in organisms |
| describe the basic catabolic reactions leading to energy production in organisms |
| explain the principles of non-covalent bonds in biopolymers and their significance |
| explain the principles of non-covalent bonds in biopolymers and their significance |
| characterize catabolism and anabolism and explain the coupling of endergonic and exergonic reactions, transfer and storage of energy obtained during catabolism |
| characterize catabolism and anabolism and explain the coupling of endergonic and exergonic reactions, transfer and storage of energy obtained during catabolism |
| explain the course of photosynthesis and nitrogen assimilation |
| explain the course of photosynthesis and nitrogen assimilation |
| describe the covalent and spatial structures of biopolymers and the principle of determining the primary structure of proteins |
| describe the covalent and spatial structures of biopolymers and the principle of determining the primary structure of proteins |
| teaching methods |
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| Knowledge |
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| Lecturing |
| Lecturing |
| Methods for working with texts (Textbook, book) |
| Methods for working with texts (Textbook, book) |
| Skills |
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| Practice exercises |
| Practice exercises |
| Dialogic (Discussion, conversation, brainstorming) |
| Dialogic (Discussion, conversation, brainstorming) |
| assessment methods |
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| Knowledge |
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| Didactic test |
| Composite examination (Written part + oral part) |
| Didactic test |
| Composite examination (Written part + oral part) |
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Recommended literature
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FUKAL, L. a kol. Od biomolekul k buňce. Praha: ÚOCHB ČSAV, 1992.
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KLÁSEK, A. Biopolymery. Skripta FT.. Praha: SNTL, 1980.
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Kolektiv autorů. Od biomolekul k buňce. 19. sv. "Org. chemie". Praha: ÚOCHB ČSAV, 1992.
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Vodrážka, Zdeněk. Bioorganická chemie. 1. vyd. Praha : SNTL, 1991. ISBN 80-03-00547-7.
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VOET, D., VOETOVÁ, J.G. Biochemie. Praha: Viktoria Publ., 1995. ISBN 80-85-605-44-9.
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