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Lecturer(s)
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Rouchal Michal, doc. Ing. Ph.D.
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Course content
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- Drug development - the painful journey from the original idea to the patient. - Modern procedures in drug synthesis (retrosynthetic analysis, combinatorial chemistry). - Total synthesis as a means for efficient acquisition of bioactive substances. - Influence of the structure and spatial orientation of the molecule on biological activity. - Determining the structure of bioactive substances using spectral methods. - Possibilities of isolating bioactive substances from natural sources. - Amino acids, peptides, proteins. - Carbohydrates, polysaccharides (cellulose, pectins, gums, mucilages). - Glycosides (phenolic glycosides, cardioglycosides, thioglycosides). - Amino acids, peptides, proteins. - Alkaloids I (purine, pyridine and piperidine alkaloids). - Alkaloids II (quinoline and isoquinoline alkaloids, indole alkaloids). - Alkaloids III (tropane alkaloids). - Saponins, tannins, natural dyes.
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Learning activities and teaching methods
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Lecturing, Methods for working with texts (Textbook, book), Practice exercises
- Preparation for examination
- 120 hours per semester
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| learning outcomes |
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| Knowledge |
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| describe the phases of development of original drugs and the differences between original and generic drugs |
| describe the phases of development of original drugs and the differences between original and generic drugs |
| characterize modern trends in drug development |
| characterize modern trends in drug development |
| describe the influence of the structure of the molecule (regioisomerism, geometric isomerism, stereoisomerism) on biological activity |
| describe the influence of the structure of the molecule (regioisomerism, geometric isomerism, stereoisomerism) on biological activity |
| characterize the spectral methods for determining the structure of biologically active compounds and describe their basic principles |
| characterize the spectral methods for determining the structure of biologically active compounds and describe their basic principles |
| characterize alkaloids derived from selected amino acids and describe their biological activities |
| characterize alkaloids derived from selected amino acids and describe their biological activities |
| Skills |
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| distinguish between original and generic drugs |
| distinguish between original and generic drugs |
| decide to which group of substances the selected alkaloids belong (according to their structural formula, biological effects, etc.) |
| decide to which group of substances the selected alkaloids belong (according to their structural formula, biological effects, etc.) |
| propose spectral methods suitable for characterizing the structure of the relevant biologically active substance |
| propose spectral methods suitable for characterizing the structure of the relevant biologically active substance |
| teaching methods |
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| Knowledge |
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| Lecturing |
| Lecturing |
| Methods for working with texts (Textbook, book) |
| Methods for working with texts (Textbook, book) |
| Skills |
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| Dialogic (Discussion, conversation, brainstorming) |
| Dialogic (Discussion, conversation, brainstorming) |
| Practice exercises |
| Practice exercises |
| assessment methods |
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| Knowledge |
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| Oral examination |
| Grade (Using a grade system) |
| Grade (Using a grade system) |
| Didactic test |
| Oral examination |
| Didactic test |
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Recommended literature
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BRAHMACHARI, G. Chemistry and Pharmacology of Naturally Occuring Bioactive Compounds, 1st Ed.. CRC Press, 2013. ISBN 978-1439891674.
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CORRADO, T. Bioactive Compounds from Natural Sources, 2nd Ed.. CRC Press, 2011. ISBN 978-1439822296.
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DOSTÁL, J. a kol. Lékařská chemie II. MU Brno, 2007. ISBN 978-80-210-3789-2.
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HAMPL, F., RÁDL, S., PALEČEK, J. Farmakochemie. Praha: VŠCHT, 2007. ISBN 978-80-7080-639-1.
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HOFMANN, A. LSD mé nezvedené dítě. Praha: Profess, 1997. ISBN 80-85235-46-3.
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MCMURRY, J. Organická chemie. Vitium Praha, 2007. ISBN 978-80-7080-637-1.
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