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Lecturer(s)
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Prucková Zdeňka, Ing. Ph.D.
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Course content
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1. Characteristics and classification of heterocycles. 2. Nomenclature of heterocycles - Hantzsch-Widman, trivial names, nomenclature of polycondensed heterocycles, nomenclature of spiro compounds and heterospiro compounds. 3. General methods for the synthesis of heterocyclic compounds. 4. Synthesis and properties of 3, 4 and 7 membered heterocycles. 5. Synthesis and properties of 5-membered heterocycles. 6. Synthesis and properties of 6-membered heterocycles. 7. Polycondensed heterocyclic compounds I. 8. Polycondensed heterocyclic compounds II. 9. Macroheterocycles - cyclodextrins, cucurbiturils, crown ethers, cryptands, porphyrins. 10. Important heterocycles of primary metabolism - function and biosynthesis. 11. Selected heterocycles of secondary metabolism of plant origin - function and biosynthesis. 12. Selected heterocycles of secondary metabolism of animal origin - function and biosynthesis. 13. Alkaloids - function, biosynthesis and total synthesis of selected substances. 14. Biological activity of synthetic heterocyclic compounds.
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Learning activities and teaching methods
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Monologic (Exposition, lecture, briefing)
- Participation in classes
- 42 hours per semester
- Home preparation for classes
- 30 hours per semester
- Preparation for examination
- 20 hours per semester
- Preparation for course credit
- 28 hours per semester
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| learning outcomes |
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| Knowledge |
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| sorting, aromaticity, pK of heterocyclic compounds |
| sorting, aromaticity, pK of heterocyclic compounds |
| nomenclature of heterocycles, including condensed ones |
| nomenclature of heterocycles, including condensed ones |
| syntheses of heterocyclic compounds, including condensed ones |
| syntheses of heterocyclic compounds, including condensed ones |
| reactions of heterocyclic compounds |
| reactions of heterocyclic compounds |
| biological properties of heterocycles and alkaloids |
| biological properties of heterocycles and alkaloids |
| Skills |
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| Name complicated heterocyclic compounds. |
| Name complicated heterocyclic compounds. |
| Suggest a synthesis of of basic heterocyclic compounds. |
| Suggest a synthesis of of basic heterocyclic compounds. |
| Determine the properties and reactivity of individual basic heterocycles. |
| Determine the properties and reactivity of individual basic heterocycles. |
| Clarify the biological properties of basic heterocyclic compounds. |
| Clarify the biological properties of basic heterocyclic compounds. |
| Describe the main representatives of alkaloids and determine their biological activity. |
| Describe the main representatives of alkaloids and determine their biological activity. |
| teaching methods |
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| Knowledge |
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| Monologic (Exposition, lecture, briefing) |
| Monologic (Exposition, lecture, briefing) |
| Methods for working with texts (Textbook, book) |
| Methods for working with texts (Textbook, book) |
| Skills |
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| Dialogic (Discussion, conversation, brainstorming) |
| Dialogic (Discussion, conversation, brainstorming) |
| Practice exercises |
| Practice exercises |
| assessment methods |
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| Knowledge |
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| Written examination |
| Grade (Using a grade system) |
| Grade (Using a grade system) |
| Written examination |
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Recommended literature
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AMETA, K.L., DANDIA, A. Multicomponent Reactions: Synthesis of Bioactive Heterocycles.. CRC Press, 2017. ISBN 978-1498734127.
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AMETA, K.L., PAWAR, R.P., DOMB, A.J. Bioactive Heterocycles: Synthesis & Biological Evaluation (Biochemistry Research Trends).. Nova Science Publishers, 2013. ISBN 978-1622576364.
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ČERVINKA, O. a kol. Chemie organických sloučenin II.. Praha: SNTL, 1987.
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JOULE, J.A., MILES, K. Heterocyclic Chemistry. 5th Ed.. Wiley-Blackwell, 2010. ISBN 978-1-4051-3300-5.
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KATRITZKY, A.R. Handbook of Heterocyclic Chemistry.. Burlington Elsevier Science, 2013. ISBN 978-0-0802-6217-8.
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KOVÁČ, J., KRUTOŠÍKOVÁ, A., KADA, R. Chémia heterocyklických zlúčenín.. Bratislava: Veda, 1982.
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STANĚK, J. Alkaloidy.. Praha: Nakladatelství ČSAV, 1957.
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