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Lecturer(s)
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Vícha Robert, doc. Mgr. Ph.D.
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Rouchal Michal, doc. Ing. Ph.D.
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Dastychová Lenka, RNDr. Ph.D.
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Prucková Zdeňka, Ing. Ph.D.
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Course content
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1. Nature of supramolecular interactions. Ionic interactions, ion-dipole interactions, H-bond, cation-pi interaction, pi-pi stacking, van der Waals interactions, hydrophobic interactions. 2. Molecular recognition. 3. Methods for supramolecular complexes structure and binding properties determination. Complex stoichiometry, definition and determination of binding constants. MS, UV-VIS titrations, NMR titrations (fast vs. slow exchange), isothermal calorimetric titrations. 4. Structure determination using 2D-NMR techniques (NOESY, ROESY, NOESY-HMQC) and X-ray difraction analysis. 5. Cations binding systems. Crown-ethers, cryptands, spherands, cucurbiturils, calyxarens. 6. Anions binding systems. Binding behaviour as a funtion of pH. Guanidine receptors. Bambusuriles. Receptors for hydride anion. 7. Neutral molecules binding systems. Clathrathes, zeolites, urea clathrathes. 8. Cyklodextrins - structure, binding properties, applications. Cyklophanes, carcerands. 9. Self-assembly systems. Catenanes, rotaxanes, helicates. 10. Molecular devices. 11. Liquid crystals. 12. Supramolecular polymers, gels. 13. Catalysis related to supramolecular complexes. 14. Supramolecular nature of photosynthesis and oxygen transport.
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Learning activities and teaching methods
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Monologic (Exposition, lecture, briefing), Practice exercises, Individual work of students
- Participation in classes
- 22 hours per semester
- Home preparation for classes
- 24 hours per semester
- Preparation for course credit
- 44 hours per semester
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| prerequisite |
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| Knowledge |
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| Intermediate knowledge of organic, physical and instrumental analytical chemistry. The interest in chemistry and desire for self-education are the most important prerequisites. |
| Intermediate knowledge of organic, physical and instrumental analytical chemistry. The interest in chemistry and desire for self-education are the most important prerequisites. |
| learning outcomes |
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| The student can list and describe the basic types of macrocyclic hosts and their complementary ligands. |
| The student can list and describe the basic types of macrocyclic hosts and their complementary ligands. |
| The student can define structural assumptions and clarify the principles of intermolecular interactions. |
| The student can define structural assumptions and clarify the principles of intermolecular interactions. |
| The student can demonstrate the principles of catalysis using macrocyclic hosts. |
| The student can demonstrate the principles of catalysis using macrocyclic hosts. |
| The student can decide on the appropriate instrumental methods of describing the given systems. |
| The student can decide on the appropriate instrumental methods of describing the given systems. |
| Skills |
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| The student can design basic experiments for determining association constants using NMR. |
| The student can design basic experiments for determining association constants using NMR. |
| The student can apply relations for the equilibrium constant and calculate the concentrations of components in an equilibrium mixture. |
| The student can apply relations for the equilibrium constant and calculate the concentrations of components in an equilibrium mixture. |
| teaching methods |
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| Knowledge |
|---|
| Monologic (Exposition, lecture, briefing) |
| Monologic (Exposition, lecture, briefing) |
| Dialogic (Discussion, conversation, brainstorming) |
| Dialogic (Discussion, conversation, brainstorming) |
| Skills |
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| Individual work of students |
| Individual work of students |
| Practice exercises |
| Practice exercises |
| assessment methods |
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| Knowledge |
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| Written examination |
| Analysis of the student's performance |
| Analysis of the student's performance |
| Written examination |
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Recommended literature
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DIEDERICH, F., STANG, P.J., TYKWINSKI, R.R. Modern Supramolecular Chemistry. Chichester: John Wiley & Sons, Ltd., 2008. ISBN 978-3-527-31826-1.
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Helena Dodziuk. Cyclodextrins and Their Complexes. 2006. ISBN 978-3-527-31280-1.
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J.-M. Lehn. Supramolecular Chemistry: Concepts and Perspectives. Weinheim. ISBN 3-527-29311-6.
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Kimoon Kim. Cucurbiturils and related macrocycles. 2019. ISBN 978-1-78801-500-4.
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P. D. Beer, P. A. Gale, D. K. Smith. Supramoelcular Chemistry. Oxford, 1999. ISBN 0-19-850447-0.
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SCHEIDER, H.J., YATSIMIRSKY, A. Principles and Methods in Supramolecular Chemistry. Chichester: John Wiley & Sons, Ltd., 2000. ISBN 0-417-97253-3.
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STEED, J.W., ATWOOD, J.L. Supramolecular Chemistry. Chichester: John Wiley & Sons, Ltd., 2000. ISBN 0-471- 98791-3.
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Stefan Kubik. Supramolecular Chemistry. Berlin, 2021. ISBN 978-3-11-059560-4.
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