Course: Medicinal Chemistry

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Course title Medicinal Chemistry
Course code TUCH/TE8MC
Organizational form of instruction Lecture
Level of course Master
Year of study not specified
Semester Summer
Number of ECTS credits 4
Language of instruction English
Status of course unspecified
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
Course availability The course is available to visiting students
Lecturer(s)
  • Kafka Stanislav, doc. Ing. CSc.
Course content
- Basic concepts and definitions, principles of interaction of organism and drugs, the development stages of pharmaceuticals. - Analgesics. - Drugs of the central nervous system - general anesthetics, sedatives and hypnotics. - Drugs of the central nervous system - psychopharmaceuticals. - Autonomic nervous system drugs - adrenergic and antiadrenergic drugs. - Autonomic nervous system drugs - cholinergic and anticholinergic drugs. Musculotropic antispasmodic drugs. - Local anesthetics, antitussives and expectorants. - Antialergics and antihistaminics. - Cardiovascular drugs. - Drugs of the gastrointestinal system. - Anti-infective and anti-invasive agents. - Antineoplastics. - Dermatologic drugs. - Methods of drug design, good manufacturing practice.

Learning activities and teaching methods
Monologic (Exposition, lecture, briefing), Practice exercises
  • Preparation for course credit - 10 hours per semester
  • Preparation for examination - 20 hours per semester
  • Participation in classes - 42 hours per semester
  • Home preparation for classes - 28 hours per semester
Learning outcomes
The subject is aimed at the introduction into the topics of general medicinal chemistry. Student will acquire fundamentals in the systematical medicinal chemistry, including the overview about structures and syntheses of the most frequented drugs.
The student is well informed in the general medicinal chemistry, uses basic terms and definitions, understands to the principles of organism - drug interactions. He/she has knowledge about methods used in drugs design and rules for drugs registration. He/she is able to implement good production practice policy.
Prerequisites
Knowledge gained in courses Organic chemistry I, Organic chemistry II, Methods of synthesis of organic substances.

Assessment methods and criteria
Grade (Using a grade system), Written examination

Attendance: compulsory at the first lecture, at the lecture comprising a written test, in which the minimum requirement is one half of the maximum points; if the student fails to pass the test, he/she must resit for the test. Compulsory attendance in seminars. Course credit: one half of the maximum points from the written test is the minimum requirement to receive the course credit. Examination: knowledge of the curriculum content already dealt with, written exam. The result of a subject examination is expressed on a six-point scale: A "výborně" (i.e. "excellent"), B "velmi dobře" (i.e. "very good"), C "dobře" (i.e. "good"), D "uspokojivě" (i.e. "satisfactory"), E "dostatečně" (i.e. "sufficient"), F "nedostatečně" (i.e. "fail").
Recommended literature
  • Hampl, F., Rádl, S., Paleček, J. Farmakochemie. Praha, 2015.
  • Hanika, J. Farmaceutické inženýrství. Praha: VŠCHT, 2013.
  • Hynie, S. Farmakologie v kostce. 2. vyd.. Praha: Triton, 2009.
  • KLEEMANN, A., ENGEL, J., KUTSCHER, B., REICHERT, D. Pharmaceutical Substances, Syntheses, Patents, Applications. 5th Ed.. Stuttgart: Thieme, 2009.
  • Komárek, P., Rabišková, M. Technologie léků. 3. vyd.. Praha: Galén, 2006.
  • Kuchař, M. a kol. Farmaceutický encyklopedický slovník. Praha, 2014. ISBN 978-80-7080-876-4.
  • Lincová, Dagmar. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha : Galén, 2007. ISBN 978-80-7262-373-0.
  • LÜLLMANN, H., MOHR, K., WEHLING, M. Farmakologie a toxikologie. Praha: Grada Publishing, 2004.


Study plans that include the course
Faculty Study plan (Version) Category of Branch/Specialization Recommended year of study Recommended semester