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Lecturer(s)
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Kafka Stanislav, doc. Ing. CSc.
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Course content
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- Reduction of multiple bonds between hydrogen atoms, hydrogenolysis. - Reduction of functional groups containing oxygen, nitrogen and sulfur atoms. - Oxidation of hydrocarbons. - Oxidation of hydrocarbons derivatives. - Introduction of halogen atoms into molecules addition of hydrogen halides, halogens and hypohalous acids on C=C, displacement of hydrogen atom with a halogen atom. - Introduction of halogen atoms into molecules displacement of hydroxyl group with a halogen atom, conversion of carbonyl compounds into geminal dihalogen derivatives, displacement of a halogen atom with other halogen atom, displacement of a metal atom with a halogen atom. - Nitration, nitrosation and sulfonation. - Alkylation of aliphatic compounds. - Alkylation and acylation of aromatic compounds. - Preparation of organometallic compounds, conversions and synthetic use of especially organomagnesium, organolithium and organozinc compounds. - Diazotisation, displacement of the diazonium group leading to the formation of oxygen, nitrogen and sulfur containing derivatives, azo coupling reactions, carbon-carbon bond formation. - Knoevenagel reaction, phosphorus ylides, Wittig reaction, Horner - Wadsworth - Emmons reaction. - Darzens reaction, sulfur ylides and their exploitation for the preparation of oxirane derivatives. - Protecting groups in organic synthesis. Protection for the hydroxyl, carbonyl, carboxyl and amino groups.
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Learning activities and teaching methods
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Lecturing, Monologic (Exposition, lecture, briefing)
- Preparation for examination
- 150 hours per semester
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| prerequisite |
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| Knowledge |
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| Knowledge of organic chemistry. |
| Knowledge of organic chemistry. |
| learning outcomes |
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| methods of reduction and oxidation of organic compounds |
| methods of reduction and oxidation of organic compounds |
| methods of introduction of halogen atoms and nitrogen or sulfur containing groups into molecules of organic compounds |
| methods of introduction of halogen atoms and nitrogen or sulfur containing groups into molecules of organic compounds |
| use of elimination reactions in the syntheses of organic compounds |
| use of elimination reactions in the syntheses of organic compounds |
| methods of carbon chains building by means of alkylation and acylation reactions and with the use of P-ylides |
| methods of carbon chains building by means of alkylation and acylation reactions and with the use of P-ylides |
| possibilities of selective protection of functional groups in multi-step syntheses |
| possibilities of selective protection of functional groups in multi-step syntheses |
| Skills |
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| to propose a method for carrying out a certain type of chemical transformation of the starting compound |
| to propose a method for carrying out a certain type of chemical transformation of the starting compound |
| to propose a method of selective carrying out of the reduction of a certain group beside other reducible groups in the molecule |
| to propose a method of selective carrying out of the reduction of a certain group beside other reducible groups in the molecule |
| to propose a method of selectively carrying out of the oxidation of a certain group beside other oxidizable groups in the molecule |
| to propose a method of selectively carrying out of the oxidation of a certain group beside other oxidizable groups in the molecule |
| to assess the suitability of various reagents used for a given type of substrate conversion for application to a particular substrate |
| to assess the suitability of various reagents used for a given type of substrate conversion for application to a particular substrate |
| to assess the possibilities of influencing the given transformation by the reaction conditions |
| to assess the possibilities of influencing the given transformation by the reaction conditions |
| teaching methods |
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| Knowledge |
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| Lecturing |
| Lecturing |
| Dialogic (Discussion, conversation, brainstorming) |
| Dialogic (Discussion, conversation, brainstorming) |
| Skills |
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| Practice exercises |
| Practice exercises |
| assessment methods |
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| Knowledge |
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| Written examination |
| Grade (Using a grade system) |
| Grade (Using a grade system) |
| Written examination |
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Recommended literature
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Červinka O. a kol. Chemie organických sloučenin. SNTL Praha, 1985.
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McMurry, J. Organická chemie. Brno: VUTIUM, 2007.
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Svoboda J. a kol. Organická syntéza I. Praha, VŠChT, 2000. ISBN 80-7080-385-1.
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