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Lecturer(s)
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Jančová Petra, Mgr. Ph.D.
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Course content
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1) Introduction to the subject - history and specialization of toxicology. Basic concepts. 2) Toxicokinetics and toxicodynamics. 3) Organ toxicity. 4) Genotoxicity (carcinogens, mutagens, teratogens). 5) Experimental toxicology (in vitro tests, in vivo animal tests, biological exposure tests); alternative methods for in silico toxicity testing of chemicals. 6) Toxicologically relevant inorganic compounds in the environment and food. 7) Radioactive substances. 8) Toxicologically significant organic compounds in the environment and food. 9) Narcotic and psychotropic substances. Natural poisons. 10) Food toxicology - mycotoxins, phycotoxins, bacterial toxins. 11) Food toxicology - food supplements, food additives, toxic substances produced during food processing. 12) Clinical toxicology (elimination of xenobiotics from the organism, antidotes). 13) Analytical toxicology (identification of nox and their metabolites). 14) Legislation and work with poisons and other harmful substances.
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Learning activities and teaching methods
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Lecturing
- Participation in classes
- 28 hours per semester
- Preparation for examination
- 28 hours per semester
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| prerequisite |
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| Knowledge |
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| Knowledge of inorganic and organic chemistry and basics of human biology. |
| Knowledge of inorganic and organic chemistry and basics of human biology. |
| learning outcomes |
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| list and describe the different phases of toxicokinetics |
| list and describe the different phases of toxicokinetics |
| characterize the mechanisms of action of toxic substances |
| characterize the mechanisms of action of toxic substances |
| describe the effects of toxicologically important inorganic compounds |
| describe the effects of toxicologically important inorganic compounds |
| characterize the major groups of organic toxicants (especially persistent organic pollutants) and describe their effect |
| characterize the major groups of organic toxicants (especially persistent organic pollutants) and describe their effect |
| describe toxicity tests (in vitro, in vivo, in silico) |
| describe toxicity tests (in vitro, in vivo, in silico) |
| Skills |
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| define the toxic effects of toxicologically significant inorganic compounds present in food or environmental components |
| define the toxic effects of toxicologically significant inorganic compounds present in food or environmental components |
| define the toxic effects of toxicologically significant organic compounds present in food or environmental components |
| define the toxic effects of toxicologically significant organic compounds present in food or environmental components |
| describe the possibilities of toxicity testing in different models (in vitro, in vivo, in silico) |
| describe the possibilities of toxicity testing in different models (in vitro, in vivo, in silico) |
| orientate on the possibilities of poisoning therapy (elimination of poisons, antidotes) |
| orientate on the possibilities of poisoning therapy (elimination of poisons, antidotes) |
| orientate on the legislation concerning the handling of poisons and other harmful substances |
| orientate on the legislation concerning the handling of poisons and other harmful substances |
| teaching methods |
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| Knowledge |
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| Lecturing |
| Lecturing |
| Methods for working with texts (Textbook, book) |
| Methods for working with texts (Textbook, book) |
| Skills |
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| Dialogic (Discussion, conversation, brainstorming) |
| Dialogic (Discussion, conversation, brainstorming) |
| Observation |
| Observation |
| assessment methods |
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| Knowledge |
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| Written examination |
| Written examination |
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Recommended literature
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Hirt, M. Toxikologie a jiné laboratorní metody ve forenzní praxi. Brno, 2011. ISBN 978-80-210-5477-6.
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Klaassen, C.D. Casarett and Doull´s Toxicology: The Basic Science of Poisons. 8th Ed.. McGraw-Hill Professional, 2013. ISBN 978-0-07-176922-8.
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KLUSOŇ, P. Toxikologie. Ústí nad Labem: FŽP UJEP, 2014. ISBN 978-80-7414-834-7.
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LINHART, I. Toxikologie: Interakce škodlivých látek s živými organismy, jejich mechanismy, projevy a důsledky. VŠCHT Praha. 2022.
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Prokeš J. Základy toxikologie. Praha, 2005. ISBN 80-7262-301-X.
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PÜSSA, T. Principles of Food Toxikology. 2nd Ed. Boca Raton: CRC Press, Taylor & Francis Group. 2014.
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